Undercarboxylated osteocalcin, muscle strength and indices of bone health in older women

I Levinger; D Scott; GC Nicholson; AL Stuart; G Duque; T McCorquodale; M Herrmann; PR Ebeling; KM Sanders

Journal article

Undercarboxylated osteocalcin, muscle strength and indices of bone health in older women

I Levinger, D Scott, GC Nicholson, AL Stuart, G Duque, T McCorquodale, M Herrmann, PR Ebeling, KM Sanders

Bone | Published : 2014

DOI: 10.1016/j.bone.2014.03.008

Abstract

We investigated the association between undercarboxylated osteocalcin (ucOC) and lower-limb muscle strength in women over the age of 70. years. The study also aims to confirm the association between bone turnover markers and heel ultrasound measures. A post-hoc analysis using data collected as part of a randomized placebo-controlled trial of vitamin D supplementation. An immunoassay was used to quantify total OC (tOC), with hydroxyapatite pre-treatment for ucOC. We determined associations of absolute and relative (ucOC/tOC; ucOC%) measures of ucOC with lower-limb muscle strength, heel ultrasound measures of speed of sound (SOS) and broadband ultrasound attenuation (BUA), bone turnover marker..

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University of Melbourne Researchers

Kerrie Sanders Author

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Grants

Awarded by Australian Government

Funding Acknowledgements

The project was funded through the National Health and Medical Research Council (#251682) with supplementary funding from the Commonwealth Department of Health and Ageing, Australian Government). Dr Itamar Levinger is a Heart Foundation Future Leader Fellow (ID: 100040) and this manuscript represents a collaboration between The University of Melbourne and Victoria University as part of the Collaborative Research Network (CRN) programme.